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Oligonucleotides targeting coagulation factor mRNAs: use in thrombosis and hemophilia research and therapy

Small interfering (si) RNAs and antisense oligonucleotides (ASOs; here for simplicity reasons, both referred to as oligonucleotides) are small synthetic RNA or DNA molecules with a sequence complementary to a (pre)mRNA. Although the basic mechanisms of action between siRNAs and ASO are distinct, a s...

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Detalhes bibliográficos
Publicado no:Thromb J
Main Authors: Heestermans, Marco, van Vlijmen, Bart J.M.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341404/
https://ncbi.nlm.nih.gov/pubmed/28286423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12959-017-0130-8
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