Mucosal delivery of anti-inflammatory IL-1Ra by sporulating recombinant bacteria

BACKGROUND: Mucosal delivery of therapeutic protein drugs or vaccines is actively investigated, in order to improve bioavailability and avoid side effects associated with systemic administration. Orally administered bacteria, engineered to produce anti-inflammatory cytokines (IL-10, IL-1Ra), have sh...

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Hlavní autoři: Porzio, Stefano, Bossù, Paola, Ruggiero, Paolo, Boraschi, Diana, Tagliabue, Aldo
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2004
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC534112/
https://ncbi.nlm.nih.gov/pubmed/15516267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-4-27
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