Mucosal delivery of anti-inflammatory IL-1Ra by sporulating recombinant bacteria

BACKGROUND: Mucosal delivery of therapeutic protein drugs or vaccines is actively investigated, in order to improve bioavailability and avoid side effects associated with systemic administration. Orally administered bacteria, engineered to produce anti-inflammatory cytokines (IL-10, IL-1Ra), have sh...

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Bibliographic Details
Main Authors: Porzio, Stefano, Bossù, Paola, Ruggiero, Paolo, Boraschi, Diana, Tagliabue, Aldo
Format: Artigo
Language:Inglês
Published: BioMed Central 2004
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC534112/
https://ncbi.nlm.nih.gov/pubmed/15516267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-4-27
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