Oral Delivery of IL27 Recombinant Bacteria Attenuates Immune Colitis in Mice

BACKGROUND & AIMS: Treatment of inflammatory bowel disease (IBD) would benefit from specific targeting of therapeutics to the intestine. We developed a strategy for localized delivery of the immunosuppressive cytokine IL27, which is actively synthesized in situ by the food-grade bacterium Lactoc...

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Autori principali: Hanson, Miranda L., Hixon, Julie A., Li, Wenqing, Felber, Barbara K., Anver, Miriam R., Stewart, C. Andrew, Janelsins, Brian M., Datta, Sandip K., Shen, Wei, McLean, Mairi H., Durum, Scott K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920828/
https://ncbi.nlm.nih.gov/pubmed/24120477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2013.09.060
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