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Oral Delivery of IL27 Recombinant Bacteria Attenuates Immune Colitis in Mice

BACKGROUND & AIMS: Treatment of inflammatory bowel disease (IBD) would benefit from specific targeting of therapeutics to the intestine. We developed a strategy for localized delivery of the immunosuppressive cytokine IL27, which is actively synthesized in situ by the food-grade bacterium Lactoc...

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Detalhes bibliográficos
Main Authors: Hanson, Miranda L., Hixon, Julie A., Li, Wenqing, Felber, Barbara K., Anver, Miriam R., Stewart, C. Andrew, Janelsins, Brian M., Datta, Sandip K., Shen, Wei, McLean, Mairi H., Durum, Scott K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920828/
https://ncbi.nlm.nih.gov/pubmed/24120477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2013.09.060
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