Interleukin 27 is a potential rescue therapy for acute severe colitis via interleukin-10 dependent, T cell independent attenuation of colonic mucosal innate immune responses

BACKGROUND: IBD patients with acute severe colitis face systemic anti-TNF biologic rescue therapy or colectomy, if treatment with intravenous steroids fail. Interleukin (IL)-27 is a cytokine with an immunosuppressive role in adaptive immune responses. However, the IL-27 receptor complex is also expr...

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Detaylı Bibliyografya
Yayımlandı:Inflamm Bowel Dis
Asıl Yazarlar: McLean, Mairi H, Andrews, Caroline, Hanson, Miranda L, Baseler, Walter A, Anver, Miriam R, Senkevitch, Emilee, Staniszewska, Aleksandra K, Smith, Christopher, Davies, Luke C, Hixon, Julie, Li, Wenqeng, Shen, Wei, Steidler, Lothar, Durum, Scott K
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5796760/
https://ncbi.nlm.nih.gov/pubmed/29019857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MIB.0000000000001274
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