Interleukin 27 is a potential rescue therapy for acute severe colitis via interleukin-10 dependent, T cell independent attenuation of colonic mucosal innate immune responses

BACKGROUND: IBD patients with acute severe colitis face systemic anti-TNF biologic rescue therapy or colectomy, if treatment with intravenous steroids fail. Interleukin (IL)-27 is a cytokine with an immunosuppressive role in adaptive immune responses. However, the IL-27 receptor complex is also expr...

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Detalhes bibliográficos
Publicado no:Inflamm Bowel Dis
Main Authors: McLean, Mairi H, Andrews, Caroline, Hanson, Miranda L, Baseler, Walter A, Anver, Miriam R, Senkevitch, Emilee, Staniszewska, Aleksandra K, Smith, Christopher, Davies, Luke C, Hixon, Julie, Li, Wenqeng, Shen, Wei, Steidler, Lothar, Durum, Scott K
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5796760/
https://ncbi.nlm.nih.gov/pubmed/29019857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MIB.0000000000001274
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