OTX2 activity at distal regulatory elements shapes the chromatin landscape of Group 3 medulloblastoma

Medulloblastoma is the most frequent malignant pediatric brain tumor and is divided into at least four subgroups known as Wnt, SHH, Group 3 and Group 4. Here we characterized gene regulation mechanisms in the most aggressive subtype, Group 3 tumors, through genome-wide chromatin and expression profi...

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Publicado en:Cancer Discov
Autores principales: Boulay, Gaylor, Awad, Mary E., Riggi, Nicolo, Archer, Tenley C., Iyer, Sowmya, Boonseng, Wannaporn E., Rossetti, Nikki E, Naigles, Beverly, Rengarajan, Shruthi, Volorio, Angela, Kim, James C., Mesirov, Jill P., Tamayo, Pablo, Pomeroy, Scott L., Aryee, Martin J., Rivera, Miguel N.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340587/
https://ncbi.nlm.nih.gov/pubmed/28213356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-0844
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