OTX2 activity at distal regulatory elements shapes the chromatin landscape of Group 3 medulloblastoma

Medulloblastoma is the most frequent malignant pediatric brain tumor and is divided into at least four subgroups known as Wnt, SHH, Group 3 and Group 4. Here we characterized gene regulation mechanisms in the most aggressive subtype, Group 3 tumors, through genome-wide chromatin and expression profi...

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Vydáno v:Cancer Discov
Hlavní autoři: Boulay, Gaylor, Awad, Mary E., Riggi, Nicolo, Archer, Tenley C., Iyer, Sowmya, Boonseng, Wannaporn E., Rossetti, Nikki E, Naigles, Beverly, Rengarajan, Shruthi, Volorio, Angela, Kim, James C., Mesirov, Jill P., Tamayo, Pablo, Pomeroy, Scott L., Aryee, Martin J., Rivera, Miguel N.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340587/
https://ncbi.nlm.nih.gov/pubmed/28213356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-0844
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