How Adverse Outcome Pathways Can Aid the Development and Use of Computational Prediction Models for Regulatory Toxicology

Efforts are underway to transform regulatory toxicology and chemical safety assessment from a largely empirical science based on direct observation of apical toxicity outcomes in whole organism toxicity tests to a predictive one in which outcomes and risk are inferred from accumulated mechanistic un...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Wittwehr, Clemens, Aladjov, Hristo, Ankley, Gerald, Byrne, Hugh J., de Knecht, Joop, Heinzle, Elmar, Klambauer, Günter, Landesmann, Brigitte, Luijten, Mirjam, MacKay, Cameron, Maxwell, Gavin, Meek, M. E. (Bette), Paini, Alicia, Perkins, Edward, Sobanski, Tomasz, Villeneuve, Dan, Waters, Katrina M., Whelan, Maurice
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Forum: AOPs, Computational Models, and Regulatory Toxicity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340205/
https://ncbi.nlm.nih.gov/pubmed/27994170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw207
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