How Adverse Outcome Pathways Can Aid the Development and Use of Computational Prediction Models for Regulatory Toxicology

Efforts are underway to transform regulatory toxicology and chemical safety assessment from a largely empirical science based on direct observation of apical toxicity outcomes in whole organism toxicity tests to a predictive one in which outcomes and risk are inferred from accumulated mechanistic un...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Toxicol Sci
Prif Awduron: Wittwehr, Clemens, Aladjov, Hristo, Ankley, Gerald, Byrne, Hugh J., de Knecht, Joop, Heinzle, Elmar, Klambauer, Günter, Landesmann, Brigitte, Luijten, Mirjam, MacKay, Cameron, Maxwell, Gavin, Meek, M. E. (Bette), Paini, Alicia, Perkins, Edward, Sobanski, Tomasz, Villeneuve, Dan, Waters, Katrina M., Whelan, Maurice
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2017
Pynciau:
Forum: AOPs, Computational Models, and Regulatory Toxicity
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340205/
https://ncbi.nlm.nih.gov/pubmed/27994170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw207
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