How Adverse Outcome Pathways Can Aid the Development and Use of Computational Prediction Models for Regulatory Toxicology

Efforts are underway to transform regulatory toxicology and chemical safety assessment from a largely empirical science based on direct observation of apical toxicity outcomes in whole organism toxicity tests to a predictive one in which outcomes and risk are inferred from accumulated mechanistic un...

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Xehetasun bibliografikoak
Argitaratua izan da:Toxicol Sci
Egile Nagusiak: Wittwehr, Clemens, Aladjov, Hristo, Ankley, Gerald, Byrne, Hugh J., de Knecht, Joop, Heinzle, Elmar, Klambauer, Günter, Landesmann, Brigitte, Luijten, Mirjam, MacKay, Cameron, Maxwell, Gavin, Meek, M. E. (Bette), Paini, Alicia, Perkins, Edward, Sobanski, Tomasz, Villeneuve, Dan, Waters, Katrina M., Whelan, Maurice
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2017
Gaiak:
Forum: AOPs, Computational Models, and Regulatory Toxicity
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340205/
https://ncbi.nlm.nih.gov/pubmed/27994170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw207
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