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Mechanism of Nucleophilic Activation of (−)-Lomaiviticin A
(−)-Lomaiviticin A (1) is a C(2)-symmetric cytotoxin that contains two diazofluorene functional groups and which induces double-strand breaks (DSBs) in DNA. Evidence suggests DNA cleavage is initiated by hydrogen atom abstraction from the deoxyribose backbone. Here we demonstrate the formation of th...
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| Udgivet i: | J Am Chem Soc |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5339879/ https://ncbi.nlm.nih.gov/pubmed/27934014 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b09657 |
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