Cargando...
Mechanism of Nucleophilic Activation of (−)-Lomaiviticin A
(−)-Lomaiviticin A (1) is a C(2)-symmetric cytotoxin that contains two diazofluorene functional groups and which induces double-strand breaks (DSBs) in DNA. Evidence suggests DNA cleavage is initiated by hydrogen atom abstraction from the deoxyribose backbone. Here we demonstrate the formation of th...
Guardado en:
| Publicado en: | J Am Chem Soc |
|---|---|
| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2016
|
| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5339879/ https://ncbi.nlm.nih.gov/pubmed/27934014 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b09657 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|