A Vascular Gene Trap Screen Defines RasGRP3 as an Angiogenesis-Regulated Gene Required for the Endothelial Response to Phorbol Esters

We identified Ras guanine-releasing protein 3 (RasGRP3) as a guanine exchange factor expressed in blood vessels via an embryonic stem (ES) cell-based gene trap screen to identify novel vascular genes. RasGRP3 is expressed in embryonic blood vessels, down-regulated in mature adult vessels, and reexpr...

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Autors principals: Roberts, David M., Anderson, Amanda L., Hidaka, Michihiro, Swetenburg, Raymond L., Patterson, Cam, Stanford, William L., Bautch, Victoria L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2004
Matèries:
Cell Growth and Development
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC533983/
https://ncbi.nlm.nih.gov/pubmed/15572660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.24.10515-10528.2004
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