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Early Origin and Evolution of the Angelman Syndrome Ubiquitin Ligase Gene Ube3a

The human Ube3a gene encodes an E3 ubiquitin ligase and exhibits brain-specific genomic imprinting. Genetic abnormalities that affect the maternal copy of this gene cause the neurodevelopmental disorder Angelman syndrome (AS), which is characterized by severe mental retardation, speech impairment, s...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Cell Neurosci
Prif Awdur: Sato, Masaaki
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339648/
https://ncbi.nlm.nih.gov/pubmed/28326016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2017.00062
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