Loading...

The Autism and Angelman Syndrome Protein Ube3A/E6AP: The Gene, E3 Ligase Ubiquitination Targets and Neurobiological Functions

UBE3A is a gene implicated in neurodevelopmental disorders. The protein product of UBE3A is the E3 ligase E6-associated protein (E6AP), and its expression in the brain is uniquely regulated via genetic imprinting. Loss of E6AP expression leads to the development of Angelman syndrome (AS), clinically...

Full description

Saved in:
Bibliographic Details
Published in:Front Mol Neurosci
Main Authors: Khatri, Natasha, Man, Heng-Ye
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6502993/
https://ncbi.nlm.nih.gov/pubmed/31114479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2019.00109
Tags: Add Tag
No Tags, Be the first to tag this record!