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Evidence for the principle of minimal frustration in the evolution of protein folding landscapes

Theoretical and experimental studies have firmly established that protein folding can be described by a funneled energy landscape. This funneled energy landscape is the result of foldable protein sequences evolving following the principle of minimal frustration, which allows proteins to rapidly fold...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Tzul, Franco O., Vasilchuk, Daniel, Makhatadze, George I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338549/
https://ncbi.nlm.nih.gov/pubmed/28196883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613892114
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