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Modulation of folding energy landscape by charge–charge interactions: Linking experiments with computational modeling

The kinetics of folding–unfolding of a structurally diverse set of four proteins optimized for thermodynamic stability by rational redesign of surface charge–charge interactions is characterized experimentally. The folding rates are faster for designed variants compared with their wild-type proteins...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Tzul, Franco O., Schweiker, Katrina L., Makhatadze, George I.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4311858/
https://ncbi.nlm.nih.gov/pubmed/25564663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410424112
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