Neuronal hyperexcitability in a mouse model of SCN8A epileptic encephalopathy

Patients with early infantile epileptic encephalopathy (EIEE) experience severe seizures and cognitive impairment and are at increased risk for sudden unexpected death in epilepsy (SUDEP). EIEE13 [Online Mendelian Inheritance in Man (OMIM) # 614558] is caused by de novo missense mutations in the vol...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Lopez-Santiago, Luis F., Yuan, Yukun, Wagnon, Jacy L., Hull, Jacob M., Frasier, Chad R., O’Malley, Heather A., Meisler, Miriam H., Isom, Lori L.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2017
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338511/
https://ncbi.nlm.nih.gov/pubmed/28193882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1616821114
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