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Gata4 potentiates second heart field proliferation and Hedgehog signaling for cardiac septation

GATA4, an essential cardiogenic transcription factor, provides a model for dominant transcription factor mutations in human disease. Dominant GATA4 mutations cause congenital heart disease (CHD), specifically atrial and atrioventricular septal defects (ASDs and AVSDs). We found that second heart fie...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zhou, Lun, Liu, Jielin, Xiang, Menglan, Olson, Patrick, Guzzetta, Alexander, Zhang, Ke, Moskowitz, Ivan P., Xie, Linglin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338429/
https://ncbi.nlm.nih.gov/pubmed/28167794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1605137114
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