Low escape-rate genome safeguards with minimal molecular perturbation of Saccharomyces cerevisiae

As the use of synthetic biology both in industry and in academia grows, there is an increasing need to ensure biocontainment. There is growing interest in engineering bacterial- and yeast-based safeguard (SG) strains. First-generation SGs were based on metabolic auxotrophy; however, the risk of cros...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Agmon, Neta, Tang, Zuojian, Yang, Kun, Sutter, Ben, Ikushima, Shigehito, Cai, Yizhi, Caravelli, Katrina, Martin, James A., Sun, Xiaoji, Choi, Woo Jin, Zhang, Allen, Stracquadanio, Giovanni, Hao, Haiping, Tu, Benjamin P., Fenyo, David, Bader, Joel S., Boeke, Jef D.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2017
Sujets:
PNAS Plus
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338387/
https://ncbi.nlm.nih.gov/pubmed/28174266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1621250114
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