Phylogenetic debugging of a complete human biosynthetic pathway transplanted into yeast

Cross-species pathway transplantation enables insight into a biological process not possible through traditional approaches. We replaced the enzymes catalyzing the entire Saccharomyces cerevisiae adenine de novo biosynthesis pathway with the human pathway. While the ‘humanized’ yeast grew in the abs...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Agmon, Neta, Temple, Jasmine, Tang, Zuojian, Schraink, Tobias, Baron, Maayan, Chen, Jun, Mita, Paolo, Martin, James A, Tu, Benjamin P, Yanai, Itai, Fenyö, David, Boeke, Jef D
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Synthetic Biology and Bioengineering
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7145547/
https://ncbi.nlm.nih.gov/pubmed/31745563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1098
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