Low escape-rate genome safeguards with minimal molecular perturbation of Saccharomyces cerevisiae

As the use of synthetic biology both in industry and in academia grows, there is an increasing need to ensure biocontainment. There is growing interest in engineering bacterial- and yeast-based safeguard (SG) strains. First-generation SGs were based on metabolic auxotrophy; however, the risk of cros...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Agmon, Neta, Tang, Zuojian, Yang, Kun, Sutter, Ben, Ikushima, Shigehito, Cai, Yizhi, Caravelli, Katrina, Martin, James A., Sun, Xiaoji, Choi, Woo Jin, Zhang, Allen, Stracquadanio, Giovanni, Hao, Haiping, Tu, Benjamin P., Fenyo, David, Bader, Joel S., Boeke, Jef D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338387/
https://ncbi.nlm.nih.gov/pubmed/28174266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1621250114
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