RhoA knockout fibroblasts lose tumor-inhibitory capacity in vitro and promote tumor growth in vivo

Fibroblasts are a main player in the tumor-inhibitory microenvironment. Upon tumor initiation and progression, fibroblasts can lose their tumor-inhibitory capacity and promote tumor growth. The molecular mechanisms that underlie this switch have not been defined completely. Previously, we identified...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Alkasalias, Twana, Alexeyenko, Andrey, Hennig, Katharina, Danielsson, Frida, Lebbink, Robert Jan, Fielden, Matthew, Turunen, S. Pauliina, Lehti, Kaisa, Kashuba, Vladimir, Madapura, Harsha S., Bozoky, Benedek, Lundberg, Emma, Balland, Martial, Guvén, Hayrettin, Klein, George, Gad, Annica K. B., Pavlova, Tatiana
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338371/
https://ncbi.nlm.nih.gov/pubmed/28174275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1621161114
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