RhoA knockout fibroblasts lose tumor-inhibitory capacity in vitro and promote tumor growth in vivo

Fibroblasts are a main player in the tumor-inhibitory microenvironment. Upon tumor initiation and progression, fibroblasts can lose their tumor-inhibitory capacity and promote tumor growth. The molecular mechanisms that underlie this switch have not been defined completely. Previously, we identified...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Alkasalias, Twana, Alexeyenko, Andrey, Hennig, Katharina, Danielsson, Frida, Lebbink, Robert Jan, Fielden, Matthew, Turunen, S. Pauliina, Lehti, Kaisa, Kashuba, Vladimir, Madapura, Harsha S., Bozoky, Benedek, Lundberg, Emma, Balland, Martial, Guvén, Hayrettin, Klein, George, Gad, Annica K. B., Pavlova, Tatiana
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338371/
https://ncbi.nlm.nih.gov/pubmed/28174275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1621161114
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