Synergistic antileukemic therapies in NOTCH1-induced T-ALL

The Notch1 gene is a major oncogenic driver and therapeutic target in T-cell acute lymphoblastic leukemia (T-ALL). However, inhibition of NOTCH signaling with γ-secretase inhibitors (GSIs) has shown limited antileukemic activity in clinical trials. Here we performed an expression-based virtual scree...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Sanchez-Martin, Marta, Ambesi-Impiombato, Alberto, Qin, Yue, Herranz, Daniel, Bansal, Mukesh, Girardi, Tiziana, Paietta, Elisabeth, Tallman, Martin S., Rowe, Jacob M., De Keersmaecker, Kim, Califano, Andrea, Ferrando, Adolfo A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2017
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338362/
https://ncbi.nlm.nih.gov/pubmed/28174276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1611831114
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