Synergistic antileukemic therapies in NOTCH1-induced T-ALL

The Notch1 gene is a major oncogenic driver and therapeutic target in T-cell acute lymphoblastic leukemia (T-ALL). However, inhibition of NOTCH signaling with γ-secretase inhibitors (GSIs) has shown limited antileukemic activity in clinical trials. Here we performed an expression-based virtual scree...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Sanchez-Martin, Marta, Ambesi-Impiombato, Alberto, Qin, Yue, Herranz, Daniel, Bansal, Mukesh, Girardi, Tiziana, Paietta, Elisabeth, Tallman, Martin S., Rowe, Jacob M., De Keersmaecker, Kim, Califano, Andrea, Ferrando, Adolfo A.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2017
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338362/
https://ncbi.nlm.nih.gov/pubmed/28174276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1611831114
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky