Computational Model Reveals Limited Correlation between Germinal Center B-Cell Subclone Abundancy and Affinity: Implications for Repertoire Sequencing

Immunoglobulin repertoire sequencing has successfully been applied to identify expanded antigen-activated B-cell clones that play a role in the pathogenesis of immune disorders. One challenge is the selection of the Ag-specific B cells from the measured repertoire for downstream analyses. A general...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Reshetova, Polina, van Schaik, Barbera D. C., Klarenbeek, Paul L., Doorenspleet, Marieke E., Esveldt, Rebecca E. E., Tak, Paul-Peter, Guikema, Jeroen E. J., de Vries, Niek, van Kampen, Antoine H. C.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5337809/
https://ncbi.nlm.nih.gov/pubmed/28321219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00221
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