Non-response to rituximab therapy in rheumatoid arthritis is associated with incomplete disruption of the B cell receptor repertoire

OBJECTIVE: To gain more insight into the dynamics of lymphocyte depletion and develop new predictors of clinical response to rituximab in rheumatoid arthritis (RA). METHODS: RNA-based next-generation sequencing was used to analyse the B cell receptor (BCR) repertoire in peripheral blood and synovial...

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Dettagli Bibliografici
Pubblicato in:Ann Rheum Dis
Autori principali: Pollastro, Sabrina, Klarenbeek, Paul L, Doorenspleet, Marieke E, van Schaik, Barbera D C, Esveldt, Rebecca E E, Thurlings, Rogier M, Boumans, Maria J H, Gerlag, Danielle M, Tak, Paul P, Vos, Koen, Baas, Frank, van Kampen, Antoine H C, de Vries, Niek
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Publishing Group 2019
Soggetti:
Rheumatoid Arthritis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6788876/
https://ncbi.nlm.nih.gov/pubmed/31217169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2018-214898
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