Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction

Every person carries a vast repertoire of CD4(+) T-helper cells and CD8(+) cytotoxic T cells for a healthy immune system. Somatic VDJ recombination at genomic loci that encode the T-cell receptor (TCR) is a key step during T-cell development, but how a single T cell commits to become either CD4(+) o...

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Xehetasun bibliografikoak
Argitaratua izan da:PLoS One
Egile Nagusiak: Klarenbeek, Paul L., Doorenspleet, Marieke E., Esveldt, Rebecca E. E., van Schaik, Barbera D. C., Lardy, Neubury, van Kampen, Antoine H. C., Tak, Paul P., Plenge, Robert M., Baas, Frank, de Bakker, Paul I. W., de Vries, Niek
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2015
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627806/
https://ncbi.nlm.nih.gov/pubmed/26517366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140815
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