Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction

Every person carries a vast repertoire of CD4(+) T-helper cells and CD8(+) cytotoxic T cells for a healthy immune system. Somatic VDJ recombination at genomic loci that encode the T-cell receptor (TCR) is a key step during T-cell development, but how a single T cell commits to become either CD4(+) o...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Klarenbeek, Paul L., Doorenspleet, Marieke E., Esveldt, Rebecca E. E., van Schaik, Barbera D. C., Lardy, Neubury, van Kampen, Antoine H. C., Tak, Paul P., Plenge, Robert M., Baas, Frank, de Bakker, Paul I. W., de Vries, Niek
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627806/
https://ncbi.nlm.nih.gov/pubmed/26517366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140815
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