Deep Sequencing of Antiviral T-Cell Responses to HCMV and EBV in Humans Reveals a Stable Repertoire That Is Maintained for Many Years

CD8(+) T-cell responses against latent viruses can cover considerable portions of the CD8(+) T-cell compartment for many decades, yet their initiation and maintenance remains poorly characterized in humans. A key question is whether the clonal repertoire that is raised during the initial antiviral r...

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Hlavní autoři: Klarenbeek, P. L., Remmerswaal, E. B. M., ten Berge, I. J. M., Doorenspleet, M. E., van Schaik, B. D. C., Esveldt, R. E. E., Koch, S. D., ten Brinke, A., van Kampen, A. H. C., Bemelman, F. J., Tak, P. P., Baas, F., de Vries, N., van Lier, R. A. W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460621/
https://ncbi.nlm.nih.gov/pubmed/23028307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002889
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