Deep Sequencing of Antiviral T-Cell Responses to HCMV and EBV in Humans Reveals a Stable Repertoire That Is Maintained for Many Years

CD8(+) T-cell responses against latent viruses can cover considerable portions of the CD8(+) T-cell compartment for many decades, yet their initiation and maintenance remains poorly characterized in humans. A key question is whether the clonal repertoire that is raised during the initial antiviral r...

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Main Authors: Klarenbeek, P. L., Remmerswaal, E. B. M., ten Berge, I. J. M., Doorenspleet, M. E., van Schaik, B. D. C., Esveldt, R. E. E., Koch, S. D., ten Brinke, A., van Kampen, A. H. C., Bemelman, F. J., Tak, P. P., Baas, F., de Vries, N., van Lier, R. A. W.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460621/
https://ncbi.nlm.nih.gov/pubmed/23028307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002889
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