An insulin-IAPP hybrid peptide is an endogenous antigen for CD4 T cells in the non-obese diabetic mouse

BDC-6.9, a diabetogenic CD4 T cell clone isolated from a non-obese diabetic (NOD) mouse, responds to pancreatic islet cells from NOD but not BALB/c mice. We recently reported that a hybrid insulin peptide (HIP), 6.9HIP, formed by linkage of an insulin C-peptide fragment and a fragment of islet amylo...

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Bibliografiske detaljer
Udgivet i:J Autoimmun
Main Authors: Wiles, Timothy A., Delong, Thomas, Baker, Rocky L., Bradley, Brenda, Barbour, Gene, Powell, Roger L., Reisdorph, Nichole, Haskins, Kathryn
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5337175/
https://ncbi.nlm.nih.gov/pubmed/27802879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2016.10.007
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