Skp2-dependent Ubiquitination and Activation of LKB1 Is Essential for Cancer Cell Survival under Energy Stress

LKB1 is activated by forming a heterotrimeric complex with STRAD and MO25. Recent studies suggest that LKB1 has pro-oncogenic functions, besides acting as a tumor-suppressor. How the LKB1 activity is maintained and how LKB1 regulates cancer development are largely unclear. Here we show that K63-link...

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Veröffentlicht in:Mol Cell
Hauptverfasser: Lee, Szu-Wei, Li, Chien-Feng, Jin, Guoxiang, Cai, Zhen, Han, Fei, Chan, Chia-Hsin, Yang, Wei-Lei, Li, Bin-Kui, Rezaeian, Abdol Hossein, Li, Hong-Yu, Huang, Hsuan-Ying, Lin, Hui-Kuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5337120/
https://ncbi.nlm.nih.gov/pubmed/25728766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.01.015
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