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High-Throughput Screens to Discover Small-Molecule Modulators of Ryanodine Receptor Calcium Release Channels
Using time-resolved fluorescence resonance energy transfer (FRET), we have developed and validated the first high-throughput screening (HTS) method to discover compounds that modulate an intracellular Ca(2+) channel, the ryanodine receptor (RyR), for therapeutic applications. Intracellular Ca(2+) re...
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| Pubblicato in: | SLAS Discov |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5337111/ https://ncbi.nlm.nih.gov/pubmed/27760856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057116674312 |
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