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Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice

Fibroblast growth factor 21 (FGF21) has emerged as an important beneficial regulator of glucose and lipid homeostasis but its levels are also abnormally increased in insulin-resistant states in rodents and humans. The synthetic retinoid Fenretinide inhibits obesity and improves glucose homeostasis i...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Morrice, Nicola, Mcilroy, George D., Tammireddy, Seshu R., Reekie, Jennifer, Shearer, Kirsty D., Doherty, Mary K., Delibegović, Mirela, Whitfield, Phillip D., Mody, Nimesh
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5335663/
https://ncbi.nlm.nih.gov/pubmed/28256636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43782
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