Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue

Fenretinide (FEN) is a synthetic retinoid that inhibits obesity and insulin resistance in high-fat diet (HFD)-fed mice and completely prevents 3T3-L1 pre-adipocyte differentiation. The aim of this study was to determine the mechanism(s) of FEN action in 3T3-L1 adipocytes and in mice. We used the 3T3...

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Publicat a:Biochem Pharmacol
Autors principals: Mcilroy, George D., Tammireddy, Seshu R., Maskrey, Benjamin H., Grant, Louise, Doherty, Mary K., Watson, David G., Delibegović, Mirela, Whitfield, Phillip D., Mody, Nimesh
Format: Artigo
Idioma:Inglês
Publicat: Elsevier Science 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4762576/
https://ncbi.nlm.nih.gov/pubmed/26592777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2015.11.017
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