Fenretinide Treatment Prevents Diet-Induced Obesity in Association With Major Alterations in Retinoid Homeostatic Gene Expression in Adipose, Liver, and Hypothalamus

The synthetic retinoid, Fenretinide (FEN), inhibits obesity and insulin resistance in mice and is in early clinical trials for treatment of insulin resistance in obese humans. We aimed to determine whether alterations in retinoic acid (RA)-responsive genes contribute to the beneficial effects of FEN...

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Detalhes bibliográficos
Main Authors: Mcilroy, George D., Delibegovic, Mirela, Owen, Carl, Stoney, Patrick N., Shearer, Kirsty D., McCaffery, Peter J., Mody, Nimesh
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2013
Assuntos:
Obesity Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581207/
https://ncbi.nlm.nih.gov/pubmed/23193184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0458
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