Neuronal human BACE1 knockin induces systemic diabetes in mice

AIMS: β-Secretase 1 (BACE1) is a key enzyme in Alzheimer’s disease pathogenesis that catalyses the amyloidogenic cleavage of amyloid precursor protein (APP). Recently, global Bace1 deletion was shown to protect against diet-induced obesity and diabetes, suggesting that BACE1 is a potential regulator...

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Publié dans:Diabetologia
Auteurs principaux: Plucińska, Kaja, Dekeryte, Ruta, Koss, David, Shearer, Kirsty, Mody, Nimesh, Whitfield, Phillip D., Doherty, Mary K., Mingarelli, Marco, Welch, Andy, Riedel, Gernot, Delibegovic, Mirela, Platt, Bettina
Format: Artigo
Langue:Inglês
Publié: Springer Berlin Heidelberg 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4901117/
https://ncbi.nlm.nih.gov/pubmed/27138913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-016-3960-1
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