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Knock-in of Mutated hTAU Causes Insulin Resistance, Inflammation and Proteostasis Disturbance in a Mouse Model of Frontotemporal Dementia

Diabetes and obesity have been implicated as risk factors for dementia. However, metabolic mechanisms and associated signalling pathways have not been investigated in detail in frontotemporal dementia. We therefore here characterised physiological, behavioural and molecular phenotypes of 3- and 8-mo...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Neurobiol
Prif Awduron: Hull, Claire, Dekeryte, Ruta, Koss, David J., Crouch, Barry, Buchanan, Heather, Delibegovic, Mirela, Platt, Bettina
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer US 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6968995/
https://ncbi.nlm.nih.gov/pubmed/31396860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-019-01722-6
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