טוען...
Neuronal human BACE1 knockin induces systemic diabetes in mice
AIMS: β-Secretase 1 (BACE1) is a key enzyme in Alzheimer’s disease pathogenesis that catalyses the amyloidogenic cleavage of amyloid precursor protein (APP). Recently, global Bace1 deletion was shown to protect against diet-induced obesity and diabetes, suggesting that BACE1 is a potential regulator...
שמור ב:
| הוצא לאור ב: | Diabetologia |
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| Main Authors: | , , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Springer Berlin Heidelberg
2016
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4901117/ https://ncbi.nlm.nih.gov/pubmed/27138913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-016-3960-1 |
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