Pooled CRISPR screening with single-cell transcriptome read-out

CRISPR-based genetic screens are accelerating biological discovery, but current methods have inherent limitations. Widely used pooled screens are restricted to simple readouts including cell proliferation and sortable marker proteins. Arrayed screens allow for comprehensive molecular readouts such a...

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Detalhes bibliográficos
Publicado no:Nat Methods
Main Authors: Datlinger, Paul, Rendeiro, André F, Schmidl, Christian, Krausgruber, Thomas, Traxler, Peter, Klughammer, Johanna, Schuster, Linda C, Kuchler, Amelie, Alpar, Donat, Bock, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5334791/
https://ncbi.nlm.nih.gov/pubmed/28099430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.4177
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