Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in CLL

The Bruton tyrosine kinase (BTK) inhibitor ibrutinib provides effective treatment for patients with chronic lymphocytic leukemia (CLL), despite extensive heterogeneity in this disease. To define the underlining regulatory dynamics, we analyze high-resolution time courses of ibrutinib treatment in pa...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Rendeiro, André F., Krausgruber, Thomas, Fortelny, Nikolaus, Zhao, Fangwen, Penz, Thomas, Farlik, Matthias, Schuster, Linda C., Nemc, Amelie, Tasnády, Szabolcs, Réti, Marienn, Mátrai, Zoltán, Alpár, Donát, Bödör, Csaba, Schmidl, Christian, Bock, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6989523/
https://ncbi.nlm.nih.gov/pubmed/31996669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14081-6
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