Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in CLL

The Bruton tyrosine kinase (BTK) inhibitor ibrutinib provides effective treatment for patients with chronic lymphocytic leukemia (CLL), despite extensive heterogeneity in this disease. To define the underlining regulatory dynamics, we analyze high-resolution time courses of ibrutinib treatment in pa...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Rendeiro, André F., Krausgruber, Thomas, Fortelny, Nikolaus, Zhao, Fangwen, Penz, Thomas, Farlik, Matthias, Schuster, Linda C., Nemc, Amelie, Tasnády, Szabolcs, Réti, Marienn, Mátrai, Zoltán, Alpár, Donát, Bödör, Csaba, Schmidl, Christian, Bock, Christoph
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6989523/
https://ncbi.nlm.nih.gov/pubmed/31996669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14081-6
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