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Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in CLL

The Bruton tyrosine kinase (BTK) inhibitor ibrutinib provides effective treatment for patients with chronic lymphocytic leukemia (CLL), despite extensive heterogeneity in this disease. To define the underlining regulatory dynamics, we analyze high-resolution time courses of ibrutinib treatment in pa...

詳細記述

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書誌詳細
出版年:Nat Commun
主要な著者: Rendeiro, André F., Krausgruber, Thomas, Fortelny, Nikolaus, Zhao, Fangwen, Penz, Thomas, Farlik, Matthias, Schuster, Linda C., Nemc, Amelie, Tasnády, Szabolcs, Réti, Marienn, Mátrai, Zoltán, Alpár, Donát, Bödör, Csaba, Schmidl, Christian, Bock, Christoph
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6989523/
https://ncbi.nlm.nih.gov/pubmed/31996669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14081-6
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