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Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in CLL
The Bruton tyrosine kinase (BTK) inhibitor ibrutinib provides effective treatment for patients with chronic lymphocytic leukemia (CLL), despite extensive heterogeneity in this disease. To define the underlining regulatory dynamics, we analyze high-resolution time courses of ibrutinib treatment in pa...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2020
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6989523/ https://ncbi.nlm.nih.gov/pubmed/31996669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14081-6 |
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