Increasing the performance of pooled CRISPR–Cas9 drop-out screening

Components of the type II CRISPR–Cas complex in bacteria have been used successfully in eukaryotic cells to facilitate rapid and accurate cell line engineering, animal model generation and functional genomic screens. Such developments are providing new opportunities for drug target identification an...

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Vydáno v:Sci Rep
Hlavní autoři: Cross, Benedict C. S., Lawo, Steffen, Archer, Caroline R., Hunt, Jessica R., Yarker, Joanne L., Riccombeni, Alessandro, Little, Annette S., McCarthy, Nicola J., Moore, Jonathan D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992892/
https://ncbi.nlm.nih.gov/pubmed/27545104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31782
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