Increasing the performance of pooled CRISPR–Cas9 drop-out screening

Components of the type II CRISPR–Cas complex in bacteria have been used successfully in eukaryotic cells to facilitate rapid and accurate cell line engineering, animal model generation and functional genomic screens. Such developments are providing new opportunities for drug target identification an...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Cross, Benedict C. S., Lawo, Steffen, Archer, Caroline R., Hunt, Jessica R., Yarker, Joanne L., Riccombeni, Alessandro, Little, Annette S., McCarthy, Nicola J., Moore, Jonathan D.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992892/
https://ncbi.nlm.nih.gov/pubmed/27545104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31782
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