The oxidized thiol proteome in aging and cataractous mouse and human lens revealed by ICAT labeling

Age‐related cataractogenesis is associated with disulfide‐linked high molecular weight (HMW) crystallin aggregates. We recently found that the lens crystallin disulfidome was evolutionarily conserved in human and glutathione‐depleted mouse (LEGSKO) cataracts and that it could be mimicked by oxidatio...

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Gepubliceerd in:Aging Cell
Hoofdauteurs: Wang, Benlian, Hom, Grant, Zhou, Sheng, Guo, Minfei, Li, Binbin, Yang, Jing, Monnier, Vincent M., Fan, Xingjun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2016
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Original Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5334568/
https://ncbi.nlm.nih.gov/pubmed/28177569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12548
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