The oxidized thiol proteome in aging and cataractous mouse and human lens revealed by ICAT labeling

Age‐related cataractogenesis is associated with disulfide‐linked high molecular weight (HMW) crystallin aggregates. We recently found that the lens crystallin disulfidome was evolutionarily conserved in human and glutathione‐depleted mouse (LEGSKO) cataracts and that it could be mimicked by oxidatio...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Wang, Benlian, Hom, Grant, Zhou, Sheng, Guo, Minfei, Li, Binbin, Yang, Jing, Monnier, Vincent M., Fan, Xingjun
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5334568/
https://ncbi.nlm.nih.gov/pubmed/28177569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12548
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