Proteomic Analysis of the Glutathione-Deficient LEGSKO Mouse Lens Reveals Activation of EMT Signaling, Loss of Lens Specific Markers, and Changes in Stress Response Proteins

PURPOSE: To determine global protein expression changes in the lens of the GSH-deficient LEGSKO mouse model of age-related cataract for comparison with recently published gene expression data obtained by RNA-Seq transcriptome analysis. METHODS: Lenses were separated into epithelial and cortical fibe...

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Gepubliceerd in:Free Radic Biol Med
Hoofdauteurs: Whitson, Jeremy A., Wilmarth, Phillip A., Klimek, John, Monnier, Vincent M., David, Larry, Fan, Xingjun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5699945/
https://ncbi.nlm.nih.gov/pubmed/28951044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2017.09.019
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