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Proteomic Analysis of the Glutathione-Deficient LEGSKO Mouse Lens Reveals Activation of EMT Signaling, Loss of Lens Specific Markers, and Changes in Stress Response Proteins
PURPOSE: To determine global protein expression changes in the lens of the GSH-deficient LEGSKO mouse model of age-related cataract for comparison with recently published gene expression data obtained by RNA-Seq transcriptome analysis. METHODS: Lenses were separated into epithelial and cortical fibe...
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| Veröffentlicht in: | Free Radic Biol Med |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5699945/ https://ncbi.nlm.nih.gov/pubmed/28951044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2017.09.019 |
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