Evidence of Dual Mechanisms of Glutathione Uptake in the Rodent Lens: A Novel Role for Vitreous Humor in Lens Glutathione Homeostasis

PURPOSE: Lens glutathione synthesis knockout (LEGSKO) mouse lenses lack de novo glutathione (GSH) synthesis but still maintain >1 mM GSH. We sought to determine the source of this residual GSH and the mechanism by which it accumulates in the lens. METHODS: Levels of GSH, glutathione disulfide (GS...

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發表在:Invest Ophthalmol Vis Sci
Main Authors: Whitson, Jeremy A., Sell, David R., Goodman, Michael C., Monnier, Vincent M., Fan, Xingjun
格式: Artigo
語言:Inglês
出版: The Association for Research in Vision and Ophthalmology 2016
主題:
Lens
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4998144/
https://ncbi.nlm.nih.gov/pubmed/27472077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.16-19592
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